Registration Dossier
Registration Dossier
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EC number: 203-626-4 | CAS number: 108-89-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Well conducted study. The study was done prior to implementation of GLPs.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List V
- Author:
- Smyth, Jr. H.F.
- Year:
- 1 954
- Bibliographic source:
- Amer. Ind. Hyg. Occup. Med. 10:61 - 68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-methylpyridine
- EC Number:
- 203-626-4
- EC Name:
- 4-methylpyridine
- Cas Number:
- 108-89-4
- Molecular formula:
- C6H7N
- IUPAC Name:
- 4-methylpyridine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- Type of wrap if used: Impervious plastic film - Duration of exposure:
- 24 hours
- Doses:
- No data
- No. of animals per sex per dose:
- Four animals used in study
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.27 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: With a density of 0.96, 0.27 ml/kg is equivalent to 0.26 g/kg or 260 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 3 (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The dermal LD50 of 4-methylpyridine in rabbits was 0.27 ml/kg or 260 mg/kg.
- Executive summary:
4-methylpyridine was investigated for acute dermal toxicity in rabbits by standard acute method. Four New Zealand White rabbits were dermally administered occlusive for 24 hours with substance applied as such. Based on results, the dermal LD50 was determined to be 0.27 ml/kg or 260 mg/kg.
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