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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 January 2017 to 20 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to same study
Related information:
Composition 1
Reason / purpose:
reference to same study
Related information:
Composition 1
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
26.6 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
>= 2.3 - <= 2.4
Details on results:
The results for the samples taken at 24, 48 and 72 hours are given in Table 1.
The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15 %. Based on this, the water solubility of the test material is given as the mean value of the analysed concentrations. No test material was detected in the pre-treated sample from the blank water mixture.

Table 1: Water solubility of the test material

Stirring time (hours)

Analysed concentration (g/L)

Mean (g/L)

MD (%)

pH

24

25.6

26.6

6.9

2.4

48

26.8

2.4

72

27.4

2.3

Conclusions:
Under the conditions of this study, the water solubility of the test material at 20 °C was 26.6 g/L.
Executive summary:

The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions.

Following a preliminary study, the flask method was considered to be the most appropriate.

Three aliquots between 3041 and 3056 mg of the test material were weighed into glass vessels. To each vessel, 20 mL double distilled water was added. The vessels were placed on a magnetic stirring device at 19.7 ± 0.2 °C where the content of each vessel was stirred at 300 rpm for 24, 48 or 72 hours. As the blank, 20 mL double distilled water was stirred for 72 hours. After the stirring period, the water phases were centrifuged and diluted prior to analysis by UPLC.

Under the conditions of this study, the water solubility of the test material at 20 °C was 26.6 g/L. The pH of the aqueous samples was 2.3 to 2.4.

Description of key information

Under the conditions of this study, the water solubility of the test material at 20 °C was 26.6 g/L.

Key value for chemical safety assessment

Water solubility:
26.6 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Following a preliminary study, the flask method was considered to be the most appropriate.

Three aliquots between 3041 and 3056 mg of the test material were weighed into glass vessels. To each vessel, 20 mL double distilled water was added. The vessels were placed on a magnetic stirring device at 19.7 ± 0.2 °C where the content of each vessel was stirred at 300 rpm for 24, 48 or 72 hours. As the blank, 20 mL double distilled water was stirred for 72 hours. After the stirring period, the water phases were centrifuged and diluted prior to analysis by UPLC.

Under the conditions of this study, the water solubility of the test material at 20 °C was 26.6 g/L. The pH of the aqueous samples was 2.3 to 2.4.