Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Biodegradation: The test item attained 48% biodegradation after 28 days and was determined to be not readily biodegradable (301 B).

Adsorption coefficient: The adsorption coefficient of the test item was determined to be > 4.27 x 10E05 with Log10 Koc > 5.63 (OECD 121 and EU Method C.19).

Additional information

Abiotic degradation; Hydrolysis

Assessment of hydrolytic stability was not carried out using Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 due to the test item as a whole being essentially insoluble in aqueous media and being a complex mixture. It was considered that the loss of test item by hydrolysis at environmental relevant pH and temperatures would be negligible.

Biodegradation

A key study was performed to assess ready biodegradability of the test item in an aerobic aqueous medium. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (1992) No. 301B, "Ready Biodegradability; CO2 Evolution Test" referenced as Method C.4-C of Commission Regulation (EC) No. 440/2008 and US EPA Fate, Transport, and Transformation Test Guidelines OCSPP 835.3110 (Paragraph (m)).

 

The test item, at a concentration of 10 mg carbon/L, was exposed to activated sewage sludge micro-organisms with mineral medium in sealed culture vessels in the dark at temperatures of between 22 and 24 °C for 28 days. The biodegradation of the test item was assessed by the determination of carbon dioxide produced. Control solutions with inoculum and the reference item, sodium benzoate, together with a toxicity control were used for validation purposes.

The test item attained 48% biodegradation after 28 days and was determined to be not readily biodegradable under the strict terms and conditions of OECD Guideline No. 301 B.

Adsorption coefficient

The key determination was carried out using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test utilised a High Performance Liquid Chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The adsorption coefficient of the test item was determined to be > 4.27 x 10E05 with Log10 Koc > 5.63.