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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 January 2017 to 10 February 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
< 0.001 other: gTOC/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.1 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
5.8
Details on results:
PRELIMINARY TEST
- The preliminary estimate of water solubility using a loading rate of 0.1 g/L was < 1.0 x 10E-03 gTOC/L at 20.0 ± 0.5 °C and pH 5.8.
- The preliminary estimate of water solubility using a loading rate of 1 g/L was < 2.03 x 10E-02 gTOC/L at 20.0 ± 0.5 °C and pH 5.8.

DEFINITIVE TEST
- The analysed concentrations of total organic carbon (TOC) obtained from the sample solutions and blanks are shown in Table 14 (below).
- Concentration (g/L) of TOC in the sample solutions at 20.0 ± 0.5 °C are shown in Table 15 (below).

TABLE 14 – ANALYSED TOC CONCENTRATIONS IN THE MAIN TEST

Sample

Concentration (mgTOC/L)

Matrix blank A

0.2519

Matrix blank B

0.3279

Sample 1A

0.5135

Sample 1B

0.4652

Sample 2A

0.4446

Sample 2B

0.4241

Sample 3A

0.5554

Sample 3B

0.5455

 

TABLE 15– CONCENTRATION OF TOC IN SAMPLE SOLUTIONS

Sample number

Concentration (gTOC/L)

Solution pH

1

< 1.0 x 10-3

5.2

2

< 1.0 x 10-3

5.2

3

< 1.0 x 10-3

5.2

Overall result: < 1.0 x 10E-03 gTOC/L at 20.0 ± 0.5 °C

Conclusions:
Water solubility of the test item was determinedby total organic carbonto be < 1.0 x 10E-03 g/L of solution at 20.0 ± 0.5 °C. The result was based on a nominal loading rate of 0.1 g/L.
Executive summary:

GUIDELINE

The determination was carried out using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

Water solubility of the test item was determinedby total organic carbon to be < 1.0 x 10E-03 g/L of solution at 20.0 ± 0.5 °C. The result was based on a nominal loading rate of 0.1 g/L.

Description of key information

Water solubility of the test item was determined by total organic carbon to be < 1.0 x 10E-03 g/L of solution at 20.0 ± 0.5 °C. The result was based on a nominal loading rate of 0.1 g/L (OECD 105 and EU Method A.6).

Key value for chemical safety assessment

Additional information

GUIDELINE

The determination was carried out using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

Water solubility of the test item was determinedby total organic carbon to be < 1.0 x 10E-03 g/L of solution at 20.0 ± 0.5 °C. The result was based on a nominal loading rate of 0.1 g/L.