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EC number: 213-579-1 | CAS number: 987-65-5
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 December 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- Adenosine 5'-(tetrahydrogen triphosphate), disodium salt
- EC Number:
- 213-579-1
- EC Name:
- Adenosine 5'-(tetrahydrogen triphosphate), disodium salt
- Cas Number:
- 987-65-5
- Molecular formula:
- C10H14N5O13P3.2Na
- IUPAC Name:
- disodium hydrogen [({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]phosphonate
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- Unknown impurities.
- Molecular formula:
- Not available as unknown impurities.
- IUPAC Name:
- Unknown impurities.
- Test material form:
- solid: crystalline
- Details on test material:
- Storage conditions: 2-8°C
Batch No: 11678500
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Since the test item contains no lager particles, sieving < 2000 µm was not necessary and the test item was used as delivered.
Results and discussion
Particle sizeopen allclose all
- Key result
- Percentile:
- D10
- Mean:
- 1.1 µm
- St. dev.:
- 0.018
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D50
- Mean:
- 12.8 µm
- St. dev.:
- 0.58
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D90
- Mean:
- 199.3 µm
- St. dev.:
- 0.9
- Remarks on result:
- other: Average result calculated from the results of two test series
Any other information on results incl. tables
Visual Microscope Analysis
(1) under a microscope with 5x magnification agglomerates can be observed
(2) under a microscope with 20x magnification agglomerates can be observed
(3) under a microscope with 50x magnification, the test item consists of almost spherical particles at lower particle sizes
Particle Size Distribution
The test item shows a bimodal particle size distribution with two peaks at approx. 4 µm and 90 µm.
Test series 1:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 1.1 | 0.003 |
| D50 | 13.4 | 0.58 |
| D90 | 198.4 | 5.91 |
Test series 2:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 1.1 | 0.015 |
| D50 | 12.3 | 0.40 |
| D90 | 200.2 | 12.26 |
Applicant's summary and conclusion
- Conclusions:
- The test item ATP, Di-Na (CAS 987-65-5) has a median particle size D50 = 12.8 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
- Executive summary:
The test item ATP, Di-Na (CAS 987 -65 -5) has a median particle size D50= 12.8 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
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