Adenosine 5'-(tetrahydrogen triphosphate), disodium salt

Stability: thermal, sunlight, metals

Administrative data

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

11 January 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

1981

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Adenosine 5'-(tetrahydrogen triphosphate), disodium salt

EC Number:

213-579-1

EC Name:

Adenosine 5'-(tetrahydrogen triphosphate), disodium salt

Cas Number:

987-65-5

Molecular formula:

C10H14N5O13P3.2Na

IUPAC Name:

disodium hydrogen [({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]phosphonate

impurity 1

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

impurity 2

Reference substance name:

Unknown impurities.

Molecular formula:

Not available as unknown impurities.

IUPAC Name:

Unknown impurities.

Test material form:

solid: crystalline

Details on test material:

Storage conditions: 2-8°C
Batch No: 11678500

Results and discussion

For thermal stability study

Test substance thermally stable:

no

Remarks:

First endothermic effect was observed in the temperature range of 110 °C – 135 °C directly followed by an exothermic effect in the temperature range of 135 – 190 °. A second exothermic effect was detected in the temperature range of 200 – 290 °C.

Operating temperature

Operating temperature 1

Key result

Operating temp.:

> 110 - < 135 °C

Remarks on result:

other: endothermic effect

Operating temperature 2

Key result

Operating temp.:

> 135 - < 190 °C

Remarks on result:

other: exothermic effect

Operating temperature 3

Key result

Operating temp.:

> 200 - < 290 °C

Remarks on result:

other: exothermic effect

Sublimation:

not determined

Transformation products:

not specified

Any other information on results incl. tables

In the temperature range of 110 °C – 135 °C, an endothermic effect was observed, which was directly followed by an exothermic effect in the temperature range of 135 – 190 °C, with a decomposition energy of -190 J/g. A second exothermic effect was detected in the temperature range of 200 – 290 °C, with a decomposition energy of -80 J/g. The test was terminated at 300 °C.

Applicant's summary and conclusion

Conclusions:

In the DSC-measurements the test item ATP, Di-Na (CAS 987-65-5) showed an endothermic effect in the temperature range of 110 °C – 135 °C, which was directly followed by an exothermic effect in the temperature range of 135 – 190 °C, with a decomposition energy of -190 J/g. A second exothermic effect was detected in the temperature range of 200 – 290 °C, with a decomposition energy of -80 J/g.

Executive summary:

In the DSC-measurements the test item ATP, Di-Na (CAS 987-65-5) showed an endothermic effect in the temperature range of 110 °C – 135 °C, which was directly followed by an exothermic effect in the temperature range of 135 – 190 °C, with a decomposition energy of -190 J/g. A second exothermic effect was detected in the temperature range of 200 – 290 °C, with a decomposition energy of -80 J/g. The test was terminated at 300 °C.