Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VIII
Author:
Carpenter, CP, Weil, CS and Smyth, HF
Year:
1974
Bibliographic source:
Toxicology and Applied Pharmacology 28, 313-319

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2.46 mL/kg bw
Based on:
test mat.
95% CL:
>= 1.79 - <= 3.39
Remarks on result:
other: Equivalent to 2510 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 is 2510 mg/kg bw.
Executive summary:

The acute oral LD50 of 2 -phenylethanol is 2.46 mL/kg bw which is equivalent to 2510 mg/kg bw based on a density of 1.0202 g/cm3.