Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VIII
Author:
Carpenter, CP, Weil, CS and Smyth, HF
Year:
1974
Bibliographic source:
Toxicology and Applied Pharmacology 28, 313-319

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
0.79 mL/kg bw
Based on:
test mat.
95% CL:
>= 0.49 - <= 1.3
Remarks on result:
other: equivalent to 806 mg/kg bw

Applicant's summary and conclusion

Conclusions:
The acute dermal LD50 of 2-phenylethanol is 0.79 mL/kg bw which is equivalent to 806 mg/kg bw (based on a density of 1.0202 g/cm3).
Executive summary:

The acute dermal LD50 of 2-phenylethanol is 0.79 mL/kg bw which is equivalent to 806 mg/kg bw (based on a density of 1.0202 g/cm3).