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EC number: 203-430-9 | CAS number: 106-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study: OECD Guideline 401 (Acute Oral Toxicity)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Oxydiethylene bis(chloroformate)
- EC Number:
- 203-430-9
- EC Name:
- Oxydiethylene bis(chloroformate)
- Cas Number:
- 106-75-2
- Molecular formula:
- C6H8Cl2O5
- IUPAC Name:
- oxydiethane-2,1-diyl dichlorocarbonate
- Details on test material:
- - Name of test material (as cited in study report): diethylenglykol bis chlorformiat (diglycol bis chloroformate)
Degree of purity not reported.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hagemann + Wiga
- Weight at study initiation: 200g (m); 180g (f).
- Fasting period before study: overnight, 15 - 20 h before treatment
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2.9, 6.3, 20, 29.4,43, 63.2 %.
MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg - Doses:
- 147, 316, 1000, 1470, 2150, 3160 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was at the begining of the study and after 3, 7, and 13 days after treatment. Observations wer severaltimes on the day of application and atleast daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 650 mg/kg bw
- 95% CL:
- 1 290 - 2 052
- Mortality:
- Deaths occurred within 2 days after dosing
- Clinical signs:
- No symptoms were noted in the animal groups at 147 and 316 mg/kg bw.
In animals at 1000 - 3160 mg/kg bw signs of toxicity included apathy, dyspnea, restlessness, staggering, tremor, ruffled fur, salivation, and poor
general state. - Body weight:
- Body weight gain was unaffected in male and female rats at 147 and 316 mg/kg bw. In all groups at 1000 - 3160 mg/kg bw body weights had decreased at 2-4 days after treatment. Thereafter surviving animals gained weight but without reaching the level of the low dose animals until the end of the 14-d observation period.
- Gross pathology:
- Animals that died: heart: right side dilatation; stomach: bleeding ulcerations (gastric corrosion); lung: distended; intestine: red mucosa, diarrheic
contents, some cases of necrotic mucosa; kidneys: tubular necrosis in one animal.
Sacrificed animals: No findings in animals at 31.6 - 316 mg/kg bw. In animals at 1000 - 3160 mg/kg bw findings in stomach: wall of forestomach
thickened; diverticle formation; gastric mucosa crinkled.
Any other information on results incl. tables
Mortality after 14 days:
--------------------------------
Dose males females
(mg/kg) (dead/exposed)
--------------------------------
147 0/5 0/5
316 0/5 0/5
1000 0/5 1/5
1470 1/5 3/5
2150 3/5 5/5
3160 4/5 5/5
--------------------------------
Deaths occurred within 2 days after dosing.
The calculated LD50 was 2103 mg/kg bw for male and 1297 mg/kg bw for female rats. The combined LD50 value was 1646 mg/kg bw.
Symptoms:
No symptoms were noted in the animal groups at 147 and 316 mg/kg bw.
In animals at 1000 - 3160 mg/kg bw signs of toxicity included apathy, dyspnea, restlessness, staggering, tremor, ruffled fur, salivation, and poor general state.
Body weight gain was unaffected in male and female rats at 147 and 316 mg/kg bw. In all groups at 1000 - 3160 mg/kg bw body
weights had decreased at 2-4 days after treatment. Thereafter surviving animals gained weight but without reaching the level of the low dose animals until the end of the 14-d observation period.
Pathology:
Animals that died: heart: right side dilatation; stomach: bleeding ulcerations (gastric corrosion); lung: distended; intestine: red mucosa, diarrheic contents, some cases of necrotic mucosa; kidneys: tubular necrosis in one animal.
Sacrificed animals: No findings in animals at 31.6 - 316 mg/kg bw. In animals at 1000 - 3160 mg/kg bw findings in stomach: wall of forestomach thickened; diverticle formation; gastric mucosa crinkled.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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