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EC number: 203-430-9 | CAS number: 106-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound DIBIS: No data available
Hydrolysis product diethylene glycol: With
high probability acutely not harmful to aquatic invertebrates.
Hydrolysis product HCl: Acutely very toxic for aquatic invertebrates (pH
dependent).
Key value for chemical safety assessment
Additional information
There are no data available regarding the toxic effect of the parent compound DIBIS (CAS 106 -75 -2) to aquatic invertebrates. The key study with the hydrolysis product diethylene glycol comes from a test with Daphnia magna. The study was performed according to German Industrial Standard DIN 38412 -11, the 24 -h EC50 was determined to be > 10000 mg/L (nominal), indicating no harmful effects (Bringmann & Kühn, 1982).
The low sensitivity of aquatic invertebrates is supported by two estimates performed with the OECD QSAR Toolbox v4.1 (BASF SE, 2018). The 48 -h EC50 values were estimated to be 28100 mg/L and 43200 mg/L. The substance is within the applicability domain of the two models.
The effect of DEG on Daphnia magna was studied according to an Environment Canada method (PTAC, 2006). Neonates were exposed to a series of 5 test concentrations and observed over 48 h (mortality). The test concentrations were analytically verified. The 48-h LC50 was determined to be 62630 mg/L (95% CL: 57630-68070 mg/L; nominal).
Further, the effect of DEG on Hyalella azteca was studied according to an Environment Canada method (PTAC, 2006). 50 animals were exposed to a series of 5 test concentrations and observed over 96 h and dead neonates counted after 48 and 96 h. The 96-h LC50 was determined to be 65980 mg/L (95% CL: 61690 -70560 mg/L; nominal, analytically verified).
Based on OECD SIDS (2004), the lowest effect value for Daphnia magna was 48 -h EC50 = 48900 mg/L (OECD 2002).
Based on the Substance Evaluation within CoRAP (ECHA, 2016), a study on the toxicity of Tigropus fulvus showed the highest sensitivity: 96 -h EC50 = 5900 mg/L.
The hydrolysis product HCl showed acutely very toxic effects due to the low pH: 48 -h EC50 = 0.492 mg/L (acid equivalents to pH 5.3; OECD, 2002).
Species |
Results |
Remarks |
Reference |
Daphnia magna |
24-h EC50 > 10000 mg/L (nominal) |
DIN 38412-11; hydroylsis product (DEG); reliability 2 |
Bringmann & Kühn (1982) |
Daphnia magna |
48-h EC50 = 0.492 mg/L (acid equivalent to pH 5.3) |
equivalent or similar to OECD 202; hydrolysis product (HCl); reliability 2 |
OECD (2002) |
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