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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 2,7 Naphthalendisulfonic acid (3861-73-2) in rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
secondary source
Title:
Acute oral toxicity study of 2,7 Naphthalendisulfonic acid (3861-73-2) in rat
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of 2,7 Naphthalendisulfonic acid (3861-73-2) on rats.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (IUPAC name): 2,7 Naphthalendisulfonic acid
- Common name: Anazolene sodium
- Molecular formula: C26H16N3O10S3.3Na
- Molecular weight: 695.591 g/mol
- Smiles notation: c12c(c(ccc1Nc1ccccc1)\N=N\c1c3c(cc(c1)S(=O)(=O)[O-])cc(S(=O)(=O)[O-])cc3O)cccc2S(=O)(=O)[O-].[Na+].[Na+].[Na+]
-InChl:1S/C26H19N3O10S3.3Na/c30-23-14-18(41(34,35)36)12-15-11-17(40(31,32)33)13-22(25(15)23)29-28-20-9-10-21(27-16-5-2-1-3-6-16)26-19(20)7-4-8-24(26)42(37,38)39;;;/h1-14,27,30H,(H,31,32,33)(H,34,35,36)(H,37,38,39);;;/q;3*+1/p-3/b29-28+;;;
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Anazolene sodium
- Molecular formula :C26H16N3O10S3.3Na
- Molecular weight :695.591 g/mol
- Substance type:organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
Details on study design:
- Other examinations performed: clinical signs
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at dose 8500 mg/kg bw in treated rats
Clinical signs:
Clinical signs like changes in urine composition, behavioral excitement ,dermatitis and other signs after systemic exposure were observed.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be >5000 mg/kg bw,when rats were treated with 2,7 Naphthalendisulfonic acid (3861-73-2) orally.
Executive summary:

Acute oral toxicity study was performed in rats using test material 2,7 Naphthalendisulfonic acid(3861-73-2).No mortality was observed at dose 5000 mg/kg bw.Clinical signs like changes in urine composition, behavioral excitement ,dermatitis and other signs after systemic exposure were observed. Hence,LD50 value was considered to be >5000 mg/kg bw,when rats were treated with 2,7 Naphthalendisulfonic acid(3861-73-2) orally.