Registration Dossier
Registration Dossier
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EC number: 201-474-3 | CAS number: 83-41-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Literature
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicological Evaluations: Potential Health Hazards of Existing Chemicals
- Author:
- Berufsgenossenschaft der chemischen Industrie
- Year:
- 1 995
- Bibliographic source:
- ISBN 3-540-59148-6; Springer-Verlag Berlin
Materials and methods
Test material
- Reference substance name:
- 3-nitro-o-xylene
- EC Number:
- 201-474-3
- EC Name:
- 3-nitro-o-xylene
- Cas Number:
- 83-41-0
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 1,2-dimethyl-3-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- No. of animals per sex per dose:
- 5
- Details on study design:
- 14-day observation period
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 110 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 380 mg/kg bw
Any other information on results incl. tables
Signs of toxicity observed included impairment of breathing, coordination and reflexes, as well as stupefaction and blood-coloured encrustation of the muzzles. In the males and females that died during the study, post-mortems revealed that the livers and spleens were pale-coloured, and the small intestine was filled with milky to orange-coloured, blood-containing (haemoccult test) fluid. No pathological effects were found on the internal organs of the rats killed at the end of the observation period (Hoechst, 1987 a).
Applicant's summary and conclusion
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