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Diss Factsheets
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EC number: 223-773-8 | CAS number: 4066-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1959-03-16 - 1959-09-07
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study conducted prior to GLP, no guideline available, deficiencies in documentation, route of application not relevant for humans or to assess systemic toxicity as possible first pass metabolism is neglected.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test item was applied via intraperitoneal injection at doses of 1 resp. 2.5 g/kg bw to each 3 male rats.
- GLP compliance:
- no
- Remarks:
- test conducted prior to GLP implementation
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- IUPAC Name:
- 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- Substance type: pure substance
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: white
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: tragacanth
- Details on exposure:
- Test item was applied as aqueous tragacanth suspension.
- Doses:
- 1 and 2.5 g/kg bw
- No. of animals per sex per dose:
- 3 males per dose
- Control animals:
- no
- Details on study design:
- - Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: highest dose tested, no symptoms of poisoning or deaths observed
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- >= 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: highest dose tested, no symptoms of poisoning or deaths observed
- Mortality:
- no deaths noted
- Clinical signs:
- no symptoms of poisoning observed
Applicant's summary and conclusion
- Conclusions:
- The study conducted prior to GLP, there is no guideline available and deficiencies in documentation were noted. The route of application is not relevant for humans or to assess systemic toxicity as possible first pass metabolism is neglected. In consequence, the study alone may not serve to justify classification, but it is not contradicting to the results obtained in the other available studies on acute toxicity, on the contrary, the results are consistent. Hence, it supports the conclusion not to classify 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan as acutely toxic.
- Executive summary:
In an acute toxicity study, groups of 3 white male rats were given a single intraperitoneal injection of 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan in tragacanth at doses of 1000 and 2500 mg/kg bw.
LD50(ip) > 2500 mg/kg bw
LD0(ip) ≥ 2500 mg/kg bw
None of the animals died during the test or showed any signs of toxicity.
2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan is classified as being of low toxicity.
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