Registration Dossier
Registration Dossier
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EC number: 258-237-2 | CAS number: 52888-49-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs- Methyl anthranilate
- Author:
- D.L.J. OPDYKE
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology; 1979, Pages 535–536
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of Methyl anthranilate (CAS No: 134-20-3) was conducted in human subjects to evaluate its irritation efficacy.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl anthranilate
- EC Number:
- 205-132-4
- EC Name:
- Methyl anthranilate
- Cas Number:
- 134-20-3
- Molecular formula:
- C8-H9-N-O2
- IUPAC Name:
- methyl 2-aminobenzoate
- Details on test material:
- - Name of test material (as cited in study report): Methyl anthranilate
- Molecular formula: C8H9NO2
- Molecular weight: 151.1641 g/mol
- Substance type: Organic
- Physical state:Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methyl anthranilate
- Molecular formula: C8H9NO2
- Molecular weight: 151.1641 g/mol
- Substance type: Organic
- Physical state:Liquid
Test animals
- Species:
- other: human
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- No Data Available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Amount / concentration applied:
- 10% in petrolatum
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- After 48 hours
- Number of animals:
- No Data Available
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No skin irritation was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not-irritating
- Conclusions:
- The test material Methyl anthranilate (CAS No: 134-20-3) was observed to be non irritant on human subjects.
- Executive summary:
The skin irritation study ofMethyl anthranilate (CAS No: 134-20-3)was performed in humans to determine its irritation potential.
During the test, 10% in petrolatum of test sample was administrated to the skin of human subject for 48 hours under closed patch.
No known cutaneous reaction was observed after 48 hours. Therefore, the test chemical Methyl anthranilate (CAS No: 134-20-3)can be considered as non irritant on human skin.
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