Registration Dossier
Registration Dossier
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EC number: 258-237-2 | CAS number: 52888-49-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of 2,6-xylidinium chloride (21436-98-6) in Rats.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus Database, U.S. National Library of Medicine, 2017.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity study of 2,6-xylidinium chloride (21436-98-6) in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-xylidinium chloride
- EC Number:
- 244-388-1
- EC Name:
- 2,6-xylidinium chloride
- Cas Number:
- 21436-98-6
- Molecular formula:
- C8H11N.ClH
- IUPAC Name:
- 2,6-xylidinium chloride
- Details on test material:
- Name: 2,6-xylidinium chloride
InChI:1S/C8H11N.ClH/c1-6-4-3-5-7(2)8(6)9;/h3-5H,9H2,1-2H3;1H
Smiles:c1(c(cccc1C)C)N.Cl
- Molecular formula :C8H12ClN
- Molecular weight :157.643 g/mol
- Substance type:organic
Constituent 1
- Specific details on test material used for the study:
- Name: 2,6-xylidinium chloride
InChI:1S/C8H11N.ClH/c1-6-4-3-5-7(2)8(6)9;/h3-5H,9H2,1-2H3;1H
Smiles:c1(c(cccc1C)C)N.Cl
- Molecular formula :C8H12ClN
- Molecular weight :157.643 g/mol
- Substance type:organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 2042 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 042 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% Mortality was observed
- Mortality:
- 50% Mortality was observed in treated rats at 2042 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2042 mg/kg bw, when rats were treated with 2,6-xylidinium chloride (21436-98-6) via oral route.
- Executive summary:
Acute oral toxicity study was conducted using test material2,6-xylidinium chloride (21436-98-6) in rats at the concentration of 2042 mg/kg bw.50% Mortality was observed at dose2042 mg/kg bw. Hence, LD50 value was considered to be2042 mg/kg bw,when rats were treated with2,6-xylidinium chloride viaoral route.
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