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EC number: 209-968-0 | CAS number: 599-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The genotoxic potential of the substance was investigated in an in vitro bacterial reverse mutation assay (Ames test) conducted using methodology similar/equivalent to OECD guideline 471 (Safepharm Laboratories Limited, 1988).
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 and E. coli WP2 uvr A- were exposed to the test material in DMSO at concentrations of 12.5. 25, 50, 100, and 200 µg/plate using the plate incorporation method both with and without S9.
Under the conditions of this study, no significant increase in the numbers of revertant colonies was recorded for any of the bacterial strains with any dose of p-cumyl phenol, either with or without metabolic activation. p-Cumyl phenol was determined to be non-mutagenic.
The genotoxic potential of the substance was investigated in an in vitro mammalian chromosome aberration test conducted per OECD Test Guideline 473 under GLP conditions (BioReliance, 2001).
Chinese hamster Ovary (CHO) cells were exposed to p-cumyl phenol at concentrations of 3.75 to 60 µg/mL in DMSO both with and without S9.
p-Cumylphenol was positive for the induction of structural aberrations in CHO cells in a non-metabolically activated system. However, p-Cumylphenol was concluded to be negative in the induction of structural aberrations in a metabolically activated system and did not induce numerical aberrations in either system.
The genotoxic potential of the substance was investigated in an in vitro mammalian cell gene mutation test conducted per OECD Test Guideline 476 under GLP conditions (BioReliance, 2001).
Mouse lymphoma L5178Y cells were exposed to test material concentrations in DMSO up to 50.0 µg/mL without metabolic activation (5.0 – 50 µg/mL) and concentrations up to 60.0 µg/mL with metabolic activation (5.0 – 60 µg/mL).
p-Cumylphenol was non mutagenic with and without S9 metabolic activation.
Justification for selection of genetic toxicity endpoint
No single study is selected as key on the basis that the different studies address different aspects of genetic toxicity and the data are therefore all considered to be key.
Short description of key information:
p-Cumyl phenol did not induce gene mutations either with or without metabolic activation in Bacterial or Mammalian cell systems in-vitro. The substance was noted as positive for the induction of structural aberrations only in CHO cells without metabolic activation. p-Cumyl phenol was negative for the induction of structural aberrations with metabolic activation and did not induce numerical aberrations either with or without activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No classification is proposed for p-cumyl phenol as the genotoxicity data is equivocal. Bacterial and mammalian cell mutation assays both indicate the substance is non-mutagenic while a single in-vitro Chromosome Aberation study was noted as positive for structural aberrations without metabolic activation only.
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