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Diss Factsheets
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EC number: 209-968-0 | CAS number: 599-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with section 7.16 of Column 2 of Annex IX, the study does not need to be conducted if it is scientifically not possible to perform the test, for instance if the analytical method is not sensitive enough.
Two studies were carried out in accordance with OECD guideline 112 using the titration method and the spectrophotometric method. Neither was successful at determining the dissociation constant therefore it is considered justified to omit the study as it is scientifically not possible to perform the test.
Key value for chemical safety assessment
Additional information
The dissociation constant for p-Cumylphenol was investigated using potentiometric titration in a GLP-compliant study performed in accordance with OECD Test Guideline 112 (Springborn Smithers Laboratories, 2009).
The pKa value of p-Cumylphenol could not be determined by potentiometric titration. Potentiometric titration of test solutions at approximately 0.090 g/L p-Cumylphenol in CO2-free water with 0.1 N sodium hydroxide failed due to precipitation of the test substance. Furthermore, potentiometric titration of test solutions at approximately 0.200 g/L in 30 % methanol with 0.01 N sodium hydroxide and 0.500 g/L p-Cumylphenol in 1.0, 10 and 30 % acetonitrile with 0.01 N and 0.1 N sodium hydroxide and 0.01 N and 0.1 N hydrochloric acid did not yield reportable results since a break in the titration curves was not observed.
The dissociation constant for p-Cumylphenol was investigated using spectrophotometric determination in a GLP-compliant study performed in accordance with OECD Test Guideline 112 (Springborn Smithers Laboratories, 2009).
The pKa could not be determined by spectrophotometric determination. Spectrophotometric determination of the 10.0 mg/L samples at pH 4, 7 and 9 did show a slight shift in the peak maximum wavelength from 197 nm to 225 nm, but there was not enough wavelength resolution or the enhancement of a peak at any other wavelength to calculate pKa.
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