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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
To be completed
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
- Test item: REACH substance = freeze-dried commercial product
- Analytical purity: 97.2%
- Purity test date: 08 March 2017
- Lot:bacth No.: WI6G16X07 after drying
- Expiration date of the lot/batch: 16 July 2018
- Appearance: Off-white to yellow crystals
- Storage: At room temperature
Key result
Temp.:
20 °C
Vapour pressure:
<= 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
<= 0 Pa

The equation of the vapour pressure regression curve of the log PT of the test item as function of the temperatures was :

log PT= -5498 x 1/T + 13.54 (r = 0.998, n = 8).

The results of the isothermal TGA analysis for the test item and the vapour pressure at 20°C and 25°C are given in Table 1 and Table 2.

Table 1: Results of the Vapour pressure Isothermal TGA Analysis

 

Temperature
[°C]

Weight loss
[µg/min]

VT
[g/cm2/h]

logVT

logPT

PT
[Pa]

150

2.14271

2.56´10-4

-3.59

0.54

3.5

 

2.28069

2.72x10-4

-3.57

0.57

3.7

160

3.51084

4.19x10-4

-3.38

0.81

6.5

 

3.65190

4.36x10-4

-3.36

0.84

6.8

170

6.12150

7.31x10-4

-3.14

1.12

13

 

6.19645

7.40x10-4

-3.13

1.13

13

180

10.2779

1.23x10-3

-2.91

1.41

26

 

10.3377

1.23x10-3

-2.91

1.41

26

VT : evaporation rate of the test item

PT :Vapour pressure

Table 2 : Vapour Pressure (PT) of the Test Item

Temperature
[°C]

logPT

PT
[Pa]

PT
[mm Hg]

20

-5.22

6.0x10-6

4.5x10-8

25

-4.90

1.2x10-5

9.3x10-8

 

The weight losses of the test item were obtained with a temperature program above the melting temperature of the test item. According to this, the vapour pressure of the test item (which was, according to the method, extrapolated to 20°C and 25°C) could be slightly overestimated.

Conclusions:
The vapour pressure of the test item was ≤ 6×10-6 Pa at 20°C, and ≤ 1.2 ×10-5 Pa at 25°C.
Executive summary:

The vapour pressure of the test item (= REACH substance) was determined in a GLP-compliant study performed in accordancen with EC A.4 method and OECD Guideline No. 104, using the isothermal TGA effusion method. The vapour pressure of the test item was determined to be ≤ 6.0×10-6 Pa at 20°C, and ≤ 1.2 ×10-5 Pa at 25°C. As the weight losses were obtained with a temperature program above the melting temperature of the test item, the vapour pressure (which was extrapolated to 20°C and 25°C) could be slightly overestimated.

Description of key information

The vapour pressure of the test item (= REACH substance) was determined in a GLP-compliant study performed in accordancen with EC A.4 method and OECD Guideline No. 104, using the isothermal TGA effusion method. The vapour pressure of the test item was determined to be ≤ 6.0×10-6 Pa at 20°C, and ≤ 1.2 ×10-5 Pa at 25°C. As the weight losses were obtained with a temperature program above the melting temperature of the test item, the vapour pressure (which was extrapolated to 20°C and 25°C) could be slightly overestimated.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the test item was investigated in one GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.