Registration Dossier

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Bacterial reverse mutation assay: The test substance, 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane (CAS 3982-82-9), was negative with and without metabolic activation in S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102 (LPT, 2002).


The studies were conducted according to an appropriate OECD test guideline, and in compliance with GLP.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Data are available from bacterial mutagenicity on registered substance 1,3,3,5-Tetramethyl-1,1,5,5 –tetraphenyltrisiloxane (CAS 3982-82-9).

The registered substance 1,3,3,5-tetramethyl-1,1,5,5–tetraphenyltrisiloxane (CAS 3982-82-9) has been tested in a valid bacterial reverse mutation assay, according to the OECD TG 471 (1989), and under GLP, using Salmonella typhimurium strains S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102 (LPT, 2002a). No increase in the number of revertants was observed in any test strain, with or without metabolic activation. Appropriate positive and solvent controls were added and gave expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.

A supporting study was also available, which confirmed the findings of the key study (DCC, 2000).


Justification for classification or non-classification

Based on the available data for 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane, no classification for genetic toxicity is required according to Regulation (EC) No. 1272/2008.