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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
α-Methyl styrene [MAK Value Documentation, 2001]
Author:
The MAK Collection for Occupational Health and Safety
Year:
2012
Bibliographic source:
The MAK Collection for Occupational Health and Safety, 138–140, 2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of 2-Phenylpropene was conducted on shaved rabbit skin to assess its irritation efficacy.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylpropene
EC Number:
202-705-0
EC Name:
2-phenylpropene
Cas Number:
98-83-9
Molecular formula:
C9H10
IUPAC Name:
2-Phenylpropene
Test material form:
liquid
Details on test material:
Name of the test chemical: 2-Phenylpropene
Molecular Weight: C9H10
Molecular Formula: 118.178 g/mol
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: 2-Phenylpropene
Molecular Weight: C9H10
Molecular Formula: 118.178 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100% (undiluted)
Duration of treatment / exposure:
2 -4 weeks (10-20 applications)
Observation period:
2 -4 weeks
Number of animals:
no data available
Details on study design:
-Type of wrap if used: bandage

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: weeks
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Moderate to severe irritation and slight necrosis was observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The rabbits showed moderate to severe irritation and slight necrosis was also observed. Hence the test chemical 2-Phenylpropene (CAS No:- 98-83-9)was considered to be irritating to the shaved skin of rabbits.
Executive summary:

A Skin irritation study was carried out inrabbitsto assess the irritation potency of 2-Phenylpropene(CAS No:- 98-83-9).Undiluted test chemical was applied to the shaved skin of rabbits skin under a bandage for 2 to 4 weeks (10 to 20 applications).

The rabbits showed moderate to severe irritation and slight necrosis was also observed. Hence, the test chemical 2-Phenylpropene(CAS No:- 98-83-9)was considered to be irritating to the shaved skin of rabbits.