Registration Dossier
Registration Dossier
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EC number: 240-915-4 | CAS number: 16883-16-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Hazard Characterization - Benzoyl Chloride (CASRN 98-88-4)
- Author:
- U. S. Environmental Protection Agency (EPA)
- Year:
- 2 012
- Bibliographic source:
- U.S. Environmental Protection Agency December, Hazard Characterization Document, 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of Benzoyl chloride was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzoyl chloride
- EC Number:
- 202-710-8
- EC Name:
- Benzoyl chloride
- Cas Number:
- 98-88-4
- Molecular formula:
- C7H5ClO
- IUPAC Name:
- Benzoyl chloride
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Benzoyl chloride
- Molecular formula: C7H5ClO
- Molecular weight: 84.1608 g/mol
- Substance type: Organic
- Physical state: liquid
- InChI: 1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
- Smiles: C1CCCCC1
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Benzoyl chloride
- Molecular formula: C7H5ClO
- Molecular weight: 84.1608 g/mol
- Substance type: Organic
- Physical state: liquid
- InChI: 1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
- Smiles: C1CCCCC1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 1210, 1820, 2420, 3030, 3750 or 6040 mg/kg
- No. of animals per sex per dose:
- Total: 60 (10 male /dose)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical examination was performed. - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 528 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- Mortality was observed at 1820(2), 2420(5), 3030(6), 3750(9) and 6040(10) mg/kg. 50% mortality was observed at dose 2528mg/kg
- Clinical signs:
- other: Signs of intoxication, sedation, extention spasm, reduced general condition of animals were observed.
- Gross pathology:
- No data available
- Other findings:
- No data available
Any other information on results incl. tables
Table – Acute oral Toxicity of Benzoyl chloride in rats.
Dose (mg/kg bw) |
Time of death |
No. of rats
|
|||
Death |
With symptoms |
No. of rats used |
|||
1.0 |
- |
0 |
0 |
10 |
|
1.5 |
3 d |
2 |
10 |
10 |
|
2.0 |
3 hrs-2 d |
5 |
10 |
10 |
|
2.5 |
3hrs-3 d |
6 |
10 |
10 |
|
3.1 |
2 d |
9 |
10 |
10 |
|
5.0 |
3 hrs-2 d |
10 |
10 |
10 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 2528 mg/kg bw, when male Wistar rats were treated with Benzoyl chloride (98-88-4) orally.
- Executive summary:
Acute oral toxicity study was conducted in 60 (10/dose) male Wistar rats using undiluted Benzoyl chloride (98-88-4). Doses were given in concentration1210, 1820, 2420, 3030, 3750 or 6040 mg/kg via oral gavage route and observed for 14 days.Mortality was observed at 1820(2), 2420(5), 3030(6), 3750(9) and 6040(10) mg/kg. 50% mortality was observed at dose 2528mg/kg bw with the Signs of intoxication, sedation, extention spasm, reduced general condition of animals were observed. Hence, LD50 was considered to be 2528mg/kg bw, when male Wistar rats were treated with Benzoyl chloride (98-88-4) orally.
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