Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-395-0 | CAS number: 467-62-9
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of 4,4',4''-Triaminotrityl alcohol (CAS no. 467 -62 -9) is predicted using OECD QSAR toolbox version 3.4 (2017) with logKow as the primary descriptor. Test substance undergoes 0.286% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 4,4',4''-Triaminotrityl alcohol was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4,4',4''-Triaminotrityl alcohol (CAS No. 467 -62 -9). If released in to the environment, 7.96% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4,4',4''-Triamino trityl alcohol in water is estimated to be 60 days (1440 hrs). The half-life 60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 4,4',4''-Triaminotrityl alcohol in sediment is estimated to be 541.66 days (13000 hrs). Based on this half-life value, it indicates that 4,4',4''-Triaminotrityl alcohol is persistent in sediment.
Biodegradation in soil
The half-life period of 4,4',4''-Triaminotrityl alcohol(CAS No. 467-62 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 86.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4,4',4''-Triaminotrityl alcohol in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of 4,4',4''-Triaminotrityl alcohol, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low .
Additional information
Biodegradation in water
Various predicted data for the target compound 4,4',4''-Triaminotrityl alcohol(CAS No. 467-62-9) and supporting weight of evidence studies for its closest read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemical4,4',4''-Triaminotrityl alcohol(CAS No. 467-62-9) was estimated.Test substance undergoes 0.286% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 4,4',4''-Triaminotrityl alcohol was estimated to be not readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound4,4',4''-Triaminotrityl alcohol(CAS No. 467-62-9) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4,4',4''-Triaminotrityl alcohol is expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database (J-CHECK, HSDB, 2017 and EnviChem, 2014) for the read across chemical 4, 4’- diaminodiphenylmethane (CAS no. 101-77-9), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 4, 4’- diaminodiphenylmethane (CAS no. 101-77-9). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) under aerobic conditions. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance 4, 4’- diaminodiphenylmethane was determined to be 0 and 5% by BOD, TOC removal and HPLC parameter in 28 days. Thus, based on percentage degradation, 4, 4’- diaminodiphenylmethane is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 1,4-diaminobenzene (CAS no. 106-50-3) (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 1,4 -diamino benzene was determined to be 5% by BOD parameter in 28 days. Thus, based on percentage degradation,1,4-diaminobenzene is considered to be not readily biodegradable in nature.
For the read across chemical 1,4-diaminobenzene (CAS no. 106-50-3) fromauthoritative database (HSDB, 2017),biodegradation study was conducted in a Warburg apparatus for 5 days for evaluating the percentage biodegradability of read across substance 1,4-diaminobenzene. The percentage degradation of substance 1,4-diaminobenzene was determined to be 0% by BOD, parameter in 5 days. Thus, based on percentage degradation,1,4 -diamino benzene is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical 4,4',4''-Triaminotrityl alcohol(from OECD QSAR toolbox version 3.4 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, HSDB and EnviChem), it can be concluded that the test substance4,4',4''-Triaminotrityl alcohol can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4,4',4''-Triaminotrityl alcohol (CAS No. 467 -62 -9). If released in to the environment, 7.96% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4,4',4''-Triamino trityl alcohol in water is estimated to be 60 days (1440 hrs). The half-life 60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 4,4',4''-Triaminotrityl alcohol in sediment is estimated to be 541.66 days (13000 hrs). Based on this half-life value, it indicates that 4,4',4''-Triaminotrityl alcohol is persistent in sediment.
Biodegradation in soil
The half-life period of 4,4',4''-Triaminotrityl alcohol(CAS No. 467-62 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 86.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4,4',4''-Triaminotrityl alcohol in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of 4,4',4''-Triaminotrityl alcohol, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low .
On the basis of available information, the test substance 4,4',4''-Triaminotrityl alcohol can be considered to be not readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
