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Diss Factsheets
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EC number: 279-919-6 | CAS number: 82205-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Three Klimisch 2 studies with structural analogues of the target substance are available in the assessment of the endpoint “Toxicity to microorganisms”. In all three studies, the inhibitory effect of the respective test substance on sewage sludge of domestic origin and/or from a laboratory scale STP was investigated after 30 min of exposure instead of a 3 h exposure period as foreseen by the current OECD Guideline 209. However, this shorter 30 min exposure period is in line with the version of OECD 209 that was applicable at the time of testing (→ OECD 209, 1984). In addition, cationic substances in particular generally adsorb strongly. This adsorption is linked to a rapid decrease of the test substance concentration in aqueous media in the presence of sewage sludge particles. Thus, a shorter exposure duration of 30 min is justified. Validity of the studies was assured by running respective positive control samples in the tests.
All three studies demonstrate significant inhibitory effects on the respiration of sewage sludge microorganisms, with 30-min EC50 values of 276 mg/L, 111 mg/L and 32 mg/L, respectively (EC50 values based on actual concentrations of active ingredients). The lowest EC50 value of 32 mg/L is associated to an EC10 of 10.2 mg/L. This EC10 value is considered the key value and is carried forward in the risk characterization of the substance.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 32 mg/L
- EC10 or NOEC for microorganisms:
- 10.2 mg/L
Additional information
The aforementioned results are used in the assessment of the target substance in a read-across approach.
For details on and justification of read-across please refer to the read-across report in section 13 of IUCLID.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.