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Diss Factsheets
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EC number: 279-919-6 | CAS number: 82205-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- August 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR prediction (BCFBAF v3.01)
- Test organisms (species):
- other: fish
- Key result
- Type:
- BCF
- Value:
- 3.162 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- not measured/tested
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The test substance is considered to have a very low potential for bioaccumulation.
- Executive summary:
The bioaccumulation potential of Basic Red 18:1 Acetate was estimated by means of BCFBAF program (v3.01) which is part of EPISuite v4.1 (US EPA). The estimation is based on the chemical structure of the substance as well as on the log Kow.
The estimation results in a BCF of 3.162 L/kg wet weight. Thus, the substance is considered to have a very low potential for bioaccumulation.
Reference
3.5 The chemical and biological mechanisms according to the model underpinning the predicted result (OECD principle 5).
-
Molecular weight: 493.98
g/mol (< 500 daltons = good absorption)
- Water solubility: >
400g/L (= soluble in water)
- Partition coefficient: log
Kow < 0.3 (> -0.4 or < 5.6 = good absorption)
- Atom count (natoms): 30
(< 70 = good bioavailability)
- H-bond acceptor (nON): 8 (< 10 = good bioavailability)
- H-bond donor (nOHNH): 1 (< 5 = good bioavailability)
Based on physico-chemical data and the results of toxicity studies, Basic Red 18:1 has a good oral, however only limited dermal bioavailability. According to its low log Kow, Basic Red 18:1 acetate does not show any potential for bioaccumulation. This is further supported by the lack of staining in organs/tissues in the repeat dose toxicity studies.
4. Adequacy (Optional)
The information is used in a weight-of-evidence approach for the assessment of the bioaccumulation potential of the substance, as part of the PBT assessment. This approach is considered adequate as experimental testing of the bioaccumulation potential in fish is not foreseen in REACH Annex VIII.
4.1 Regulatory purpose: Use in a weight-of evidence approach in the PBT assessment of the substance.
4.2 Approach for regulatory interpretation of the model result: According to REACH Annex XIII, a substance is considered bioaccumulative (B) or very bioaccumulative (vB) in case the BCF of the substance is > 2000 or > 5000, respectively.
4.3 Outcome: As the estimated BCF is3.162 L/kg wet weightand thus<< 2000, the substance is not considered to bioaccumulate.
4.4 Conclusion: The result is considered adequate for a regulatory conclusion.
Description of key information
The bioaccumulation prediction by means of the BCFBAF program (v3.01) results in a BCF of 3.162 L/kg wet weight.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.162 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.