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Description of key information

No experimental toxicokinetic study is available on Tris(2-hydroxyethyl) isocyanurate triacrylate.

However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physical-chemical properties.

Based on the toxicological data and the physicochemical properties, the absorption of Tris(2-hydroxyethyl) isocyanurate triacrylate is expected to be high by oral route and dermal route, but low after inhalation exposure.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100
Absorption rate - inhalation (%):
100

Additional information

No experimental toxicokinetic study is available on Tris(2-hydroxyethyl) isocyanurate triacrylate.

However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physical-chemical properties, including:

-Mean molecular weight: 423 g/mol

-Water solubility: 1497,3 mg/L (20°C)

-Partition coefficient Log Kow: [1,09 - 2,61] (25°C)

-Vapour pressure: 0,033 Pa (25°C)

 

ABSORPTION

Based on the molecular weight (< 500 g/mol), the moderate value of log Kow (between -1 and 4) and the high solubility (> 1000 mg/L) of Tris(2-hydroxyethyl) isocyanurate triacrylate are favorable for an oral absorption. However, no clinical effects or mortality were observed after one single administration (2000 mg/kg) of Tris(2-hydroxyethyl) isocyanurate triacrylate by gavage (oral route) in rat. An oral absorption is expected for Tris(2-hydroxyethyl) isocyanurate triacrylate, so 100% of absorption is taken into account for the risk assessment (worst case).

With a solubility of 1497,3 mg/L and a moderate Log Kow (between 1 and 4), dermal absorption is anticipated to be moderate to high. However, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Tris(2-hydroxyethyl) isocyanurate triacrylate is showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred. That's why 100% of absorption is taken into account for the risk assessment (worst case).

Based on the vapour pressure (< 0.5 Pa), Tris(2-hydroxyethyl) isocyanurate triacrylate is considered to be not a volatile substance. Indeed, the absorption by inhalation can be expected to be low for Tris(2-hydroxyethyl) isocyanurate triacrylate. However 100% of absorption is taken into account for the risk assessment (worst case).

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of Tris(2-hydroxyethyl) isocyanurate triacrylate.

No bioaccumulation is expected for this substance based on the moderate Log Low.

 

ELIMINATION

Due to the high water solubility, the excretion of Tris(2-hydroxyethyl) isocyanurate triacrylate in the urines is expected.