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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
The stability (hydrolysis) of C12-18 AAPB was calculated using EPIWIN, HYDROWIN v1.67.
GLP compliance:
no
Analytical monitoring:
no
Estimation method (if used):
The stability (hydrolysis) of C12-14 AAPB was calculated using EPIWIN v3.11, HYDROWIN v1.67.
Test performance:
The stability (hydrolysis) of C12-14 AAPB was calculated using EPIWIN v3.11, HYDROWIN v1.67.
Transformation products:
not specified
Temp.:
25 °C
DT50:
> 1 yr

HYDROWIN v1.67 Results

AMIDE: -N-C(=O)-C-

Compound has an amide group; C=O located at SMILES atom #: 2

Hydrolysis Rate Extremely Slow or t1/2> 1 Year

Validity criteria fulfilled:
not applicable
Conclusions:
The stability (hydrolysis) of C12-14 AAPB was calculated using EPIWIN, HYDROWIN v1.67. Hydrolysis is not to be expected under environmental conditions: the calculated hydrolysis half-life (t1/2) was found to be >1 year.
Executive summary:

The stability (hydrolysis) of C12 -14 AAPB was calculated using EPIWIN, HYDROWIN v1.67. Hydrolysis is not to be expected under environmental conditions: the calculated hydrolysis half-life (t1/2) was found to be >1 year.

Description of key information

A study on hydrolysis does not need to be conducted.

Key value for chemical safety assessment

Additional information

In accordance with column 2 of REACH Annex VIII, the hydrolysis test does not have to be conducted because AAPB is readily biodegradable. It is shown that biodegradation is the primary route of degradation in the environment.

In addition limited information is available from an EPIWIN calculation. However, there are no details whether the calculation model is validated for the substance under investigation, therefore reliability is not assignable. The stability (hydrolysis) of C12 -18 AAPB was calculated using EPIWIN, HYDROWIN v1.67. Hydrolysis is not to be expected under environmental conditions: the calculated hydrolysis half-life (t1/2) was found to be > 1 year.