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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
see "General Justification for Read-Across" attached to IUCLID section 13

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Mutual read across from the AAPBs to one another is justified:

a) Based on the information given in section 1, it can be concluded that all AAPBs mentioned above are similar in structure, since they are manufactured from similar resp. identical precursors under similar conditions and all contain the same functional groups. Thus a common mode of action can be assumed.
b) The content of minor constituents in all products are comparable and differ to an irrelevant amount.
c) The only deviation within this group of substances is a minor variety in their fatty acid moiety, which is not expected to have a relevant impact on intrinsic toxic or ecotoxic activity and environmental fate. Potential minor impact on specific endpoints will be discussed in the specific endpoint sections.

The read-across hypothesis is based on structural similarity of target and source substances. Based on the available experimental data, including key physico-chemical properties and data from toxicokinetic, acute toxicity, irritation, sensitisation, genotoxicity and repeated dose toxicity studies, the read-across strategy is supported by a quite similar toxicological profile of all five substances.
The respective data are summarised in the data matrix; robust study summaries are included in the Technical Dossier in the respective sections.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
see "General Justification for Read-Across" attached to IUCLID section 13

3. ANALOGUE APPROACH JUSTIFICATION
see "General Justification for Read-Across" attached to IUCLID section 13

4. DATA MATRIX
see "General Justification for Read-Across" attached to IUCLID section 13
Reason / purpose:
read-across: supporting information
Reason / purpose:
read-across source
Temp.:
20 °C
Vapour pressure:
<= 0.003 hPa
Remarks on result:
other:
Remarks:
If a rest of humidity exists, this can result in a too high value. Hence, a comparator check with an absolute dry sample would yield in a lower result.

Description of key information

A study on vapour pressure does not need to be conducted.

Key value for chemical safety assessment

Vapour pressure:
0.003 hPa
at the temperature of:
20 °C

Additional information

According to REACH Annex XI, 2. the determination of the vapour pressure of AAPB is not necessary, because it is technically not possible: the expected value of vapour pressure for the pure substance cannot be measured due to residual content of solvent (water, isopropanol) which results in a higher solvent vapour pressure than test substance vapour pressure. The residual content of solvent cannot be reduced below the limit of measurement with reasonable effort.