Registration Dossier
Registration Dossier
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EC number: 946-056-8 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Scenedesmus subspicatus (OECD 201); read-across
Key value for chemical safety assessment
Additional information
No study is available investigating the effects of the target substance Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) on aquatic algae. Thus, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance Bis(tridecyl) adipate (CAS 16958-92-2) was conducted to fulfill the data requirements according to Annex VIII. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
One study investigating the toxicity of the source substance Bis(tridecyl) adipate (CAS 16958-92-2) to freshwater algae is available. The study was conducted under static conditions according to ISO guideline 8692 using Scenedesmus subspicatus as test organism. Filtered test item solutions of loading rates between 13 and 13000 mg/L were tested. Based on cell numbers no inhibition was observed in any of the treatments. Hence, the 72 h-EL50 and the 72 h-EL10 are determined to be > 13000 mg/L based on the nominal test concentrations. The 72 h-NOELR was determined to be ≥ 13000 mg/L.
Based on the structural and chemical similarity of the target and source substance, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that the target substance Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) does not cause effects to algae up to the limit of water solubility.
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