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EC number: 298-078-6 | CAS number: 93777-46-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (21 d) > 2.8 µg/L (average measured concentration, Daphnia magna)
Key value for chemical safety assessment
Additional information
One study investigating the chronic toxicity of Decyl 2-ethylhexanoate (CAS 93777-46-9) to Daphnia magna is available. This semi-static test was conducted according to OECD 211 under GLP conditions. Daphnia magna was exposed for 21 days to the following test item concentrations: Control, 1.0, 1.8, 3.2, 5.6 and 10 µg/L (nominal) and 0.24, 0.41, 0.69, 14 and 2.8 µg/L (average measured). Due to the low solubility of the test item, Dimethylformamide (DMF, 100 µL/L) was used as a solvent for an adequate preparation of test solutions. It was initially planned to perform this study using a flow-through system. However, chemical analyses before the start of the study proved that the target concentrations could not be reached and the study was consequently continued with a semi-static test design with daily renewals of test solutions. During the study, samples for analyses were taken at the beginning and the end of four renewal intervals. Measured concentrations decreased during the 24-hour renewal periods. Results were consequently based on average measured concentrations over the 21-day test period. It was concluded that the EC10 on the reproduction of Daphnia magna is > 2.8 µg/L after 21 days and the NOEC (21 d) on reproduction is 0.41 µg/L. But there was no concentration response relationship at the three highest test concentrations (similar effects) and in the solvent control two immobile daphnids were recorded. In addition, the reduction of reproduction at the end of the test did not exceed 10% in all treatment groups. Therefore, the EC10 (21 d) of > 2.8 µg/L, which is above the water solubility of 1.82 - 2.40 µg/L, was used for evaluation and classification of the substance. It is concluded that the EC10 is the more realistic parameter to assess the observed results. The effects are not considered to be biologically relevant since they were < 10% in the three highest concentrations which were all above the water solubility. The NOEC is always dependent on the test design and does not take any biological variance into account.
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