Registration Dossier
Registration Dossier
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EC number: 201-744-0 | CAS number: 87-41-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- BASF-Test, see details in remarks on material and methods.
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test
Test material
- Reference substance name:
- Phthalide
- EC Number:
- 201-744-0
- EC Name:
- Phthalide
- Cas Number:
- 87-41-2
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 1(3H)-Isobenzofuranone
- Details on test material:
- - Name of test material (as cited in study report): Phthalid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 225 g (mean); females: 184 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- In the row data no substance loss but an increase in substance weight was recorded.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of treatment and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: Inhalation Risk Test
- Exp. duration:
- 8 h
- Remarks on result:
- not determinable because of methodological limitations
- Mortality:
- No mortality occured.
- Clinical signs:
- other: No symptoms were observed.
- Body weight:
- Animals gained normal weight.
- Gross pathology:
- No abnormalities observed.
Any other information on results incl. tables
The inhalation of a highly saturated vapour-air mixture for 8 h caused no mortality. In the row data no substance loss but an increase in substance weight was recorded.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
