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EC number: 701-023-5
CAS number: 85408-61-3
No effects up to the limit of water solubility (< 0.92 mg/L) for Desmodesmus subspicatus (OECD 201).
Since no studies investigating the toxicity to aquatic algae of Fatty
acids, C16-18 (even numbered) and C18-unsatd., branched and linear, di-
and triesters with trimethylolpropane (former CAS 85005-23-8) are
available for this endpoint, in accordance to Regulation (EC) No.
1907/2006 Annex XI, 1.5 a read across to the structurally related
category member Fatty acids, C16-18 (even numbered) and C16-18-unsatd.
(even numbered), triesters with trimethylolpropane (CAS 68002-79-9) was
conducted. Compared to Fatty acids, C16-18 (even numbered) and
C18-unsatd., branched and linear, di- and triesters with
trimethylolpropane (former CAS 85005-23-8) the read-across substance
Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered),
triesters with trimethylolpropane is characterized by similar fatty acid
component (C18 unsatd. (source substance) compared to C16-18, C18
unsatd. linear and branched (target)). Therefore, based on the
structural similarity it is possible to use the available data for the
assessment of the target substance. This read-across is justified in
detail in the overall summary (IUCLID Section 6.1) and within the
category justification in IUCLID Section 13. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment. Nevertheless, as it can be seen in the data matrix of
the category justification in section 13 and the overall summary (IUCLID
section 6.1), all reliable data in the category support the hazard
assessment of each category member by showing a consistent pattern of
The study with the read-across substance Fatty acids, C14-18 and C16-18
unsatd., triesters with trimethylolpropane (CAS 68002-79-9), was
performed according to OECD 201 (GLP) with the green algae Desmodesmus
subspicatus. An inhibition of growth rate of 24% after 72 h exposure was
observed. Therefore, the ErL50 can be derived as > 100 mg/L (WAF loading
rate). The test result shows low toxicities of the test substance far in
excess of natural occurring concentrations (water solubility < 0.92
mg/L). Therefore, the test substance is not harmful to algae.
Based on the result from one structurally related read-across substance
(in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is
characterized by a similar ecotoxicological profile and comparable
structure, it can be concluded that Fatty acids, C16-18 (even numbered)
and C18-unsatd., branched and linear, di- and triesters with
trimethylolpropane (former CAS 85005-23-8) will not exhibit effects to
aquatic algae up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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