Registration Dossier
Registration Dossier
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EC number: 231-149-1 | CAS number: 7440-39-3
Endpoint summary
Administrative data
Description of key information
Barium metal reacts with water to form the Ba(OH)2, which is a strong base that dissociates completely into Ba2+ and OH- ions, with resulting high pH level in solution (pH> 11 at 1 mM). Because the hydroxyl ions will be quickly neutralised, the assessment of barium metal is based on Barium-ion assessment, except for acute and local human health effects, which will be driven by the pH effects. Barium is manufactured and put on the market as rods of barium. To assess Ba toxicity, Ba ion data as available in the BaCl2 REACH Dossier is assessed.
From BaCl2 REACH Dossier: The reference Stitzinger (2010) is considered as the key study on skin sensitisation and will be used for classification. The overall sensitisation results are as follows:
Local lymph node assay (LLNA) in mice
SIs of less than 3.0 (1.2 – 1.5) were observed at all test concentrations of barium dichloride dihydrate (5, 10, 25 %) and no dose response could be observed. Therefore, an EC3 value (the estimated concentration required to induce a threshold positive response, i.e., SI = 3) for the test substance under the conditions of the study was not calculable.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Justification for selection of skin sensitisation endpoint:
reliable GLP guideline study with barium dichloride dihydrate available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Justification for selection of respiratory sensitisation endpoint:
During long-year industrial practice no cases of hypersensitivity were documented till now by workers exposed exclusively to barium chloride. Thus, no classification as respiratory sensitiser according to Regulation (EC) 1272/2008 is required.
Justification for classification or non-classification
Ba2+ data from BaCl2 REACH Dossier is analysed.
Sensitisation:
SIs of less than 3.0 (1.2 – 1.5) were observed at all test concentrations of barium chloride dihydrate (5, 10, 25 %) and no dose response could be observed. Therefore, an EC3 value (the estimated concentration required to induce a threshold positive response, i.e., SI = 3) for the test substance under the conditions of the study was not calculable. Thus, the classification criteria acc. to regulation (EC) 1272/2008 as skin sensitizer are not met.
Respiratory sensitisation:
During long-year industrial practice no cases of hypersensitivity were documented till now by workers exposed exclusively to barium chloride. Thus, no classification as respiratory sensitiser according to Regulation (EC) 1272/2008 is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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