Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

An estimated BCF value of 3 was calculated in fish for 4-nitro-1,3-benzenediamine ,using an estimated log Kow of 0.55 and a regression-derived equation. This BCF value suggests that the potential for bioconcentration in aquatic organisms (fish) is low.

Additional information

Bioaccumulation: aquatic / sediment

Four studies including experimental data from authorative database and predicted data from validated models for bioaccumulation (BCF) endpoint of target chemical 4-nitrobenzene-1,3-diamine (Cas no. 5131-58-8) were summarized as follows: 

 

First study for target chemical (Cas no. 5131-58 -8) which suggest an estimated BCF value of 3 was calculated in fish for 4-nitro-1,3-benzenediamine ,using an estimated log Kow of 0.55 and a regression-derived equation. This BCF value suggests that the potential for bioconcentration in aquatic organisms (fish) is low. (HSDB database by US EPA; 2017)

 

Above result is supported by prediction using BCFBAF (v3.00) model and PBT profiler which indicate the estimated bio concentration factor (BCF) for 4-nitro-1,3-benzenediamine is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that 4-nitro-1,3-benzenediamine is not expected to bio accumulate in the aquatic environment.

 

Above prediction is further assisted by Scifinder database which suggest the Bioconcentration factor (BCF) for target chemical 4-nitrobenzene-1,3-diamine was estimated to be 1.0 at pH 1, 1.68 at pH 2, 1.85-1.88 at pH range 3-10 at temperature 25 deg.C.Based on the BCF concentration at all range of pH it is concluded that the test chemical 4-nitrobenzene-1,3-diamine is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Chemspider - ACD/PhysChem Suite prediction model indicate the Bioconcentration factor (BCF) for target chemical 4-nitrobenzene-1,3-diamine was estimated to be 5.10 at pH 5.5 and 7.4 at temperature 25 deg.C. Based on the BCF concentration at two different pH concluded that the test chemical 4-nitrobenzene-1,3-diamine is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Thus based on all available studies for bioaccumulation endpoint concluded that the test substance 4-nitrobenzene-1,3-diamine (Cas no. 5131-58-8) is expected to be non Bioaccumulative in aquatic environment.