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Diss Factsheets
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EC number: 457-690-5 | CAS number: 23432-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Aug - 17 Oct 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hessisches Ministerium für Umwelt, Landwirtschaft und Forsten
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 4.6, 10, 21, 46, 100 mg/L (freshly preparred medium)
- Sampling method: Duplicate samples were taken at test start and test end.
- Sample storage conditions before analysis: samples were analysed directly - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A stock solution of 100 mg/L was prepared by suspending 602 mg test item in 6 L test water by intense stirring for 95 h. Thus, at the start of the test, the main part of the test item were hydrolysis products. Adequate volumes of the stock solution were mixed into test water to obtain the desired test concentrations. In an additional experiment a shorter stirring period of 24 h was chosen to demonstrate that the stirring period has no influence on the outcome of the study.
- Eluate: no
- Differential loading: no
- Controls: yes, test medium control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: supplied 1997 by the Umweltbundesamt, Institut für Wasser-, Boden- und Lufthygiene, Berlin, Germany
- Age at study initiation: 21 h
- Method of breeding: The daphnia were bred under the same conditions as testing conditions. The test organisms were not first brood progeny. The daphnids of the stock culture were fed at least each working day with green algae (Desmodesmus subspicatus) freshly grown in the laboratories.
- Feeding during test: none
ACCLIMATION
- Acclimation period: 21 h
- Acclimation conditions (same as test or not): same as test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.1 - 8.4 mg O2/L
- Nominal and measured concentrations:
- nominal: control, 4.6, 10, 21, 46 and 100 mg/L
measured: At the start of the test before introduction of daphnids in the concentration of 100 mg/L 100% of nominal were found. After 48 h test duration between 89 and 92% of the nominal value were determined. - Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers
- Material, size, headspace, fill volume: glass, 250 mL, heaspace: 100 mL, fill volume: 150 mL
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised water
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1 (based on molarity)
- Conductivity: < 5 µS/cm-1
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Photoperiod: 16 h light / 8 h dark
- Light intensity: 500 lux
EFFECT PARAMETERS MEASURED
- Immobility: determined by visual controls after 24 and 48 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: approx. 2.2
- Range finding study: A range-finding study was performed but not reported in detail. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but the exposure was to hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but the exposure was to hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48 h EC50 of > 100 mg/L has been determined for the effects of the test substance on mobility of Daphnia magna. The results are expressed relative to nominal concentrations of the test substance. However, the substance is subject to rapid hydrolysis and under the test conditions it is therefore likely that exposure will have been to its hydrolysis products.
Reference
In an additional experiment under identical test conditions, a limit test with a test concentration of 100 mg/L was performed by using a stirring period of 24 h, to demonstrate that the stirring period has no impact on the outcome of the study.
Description of key information
EC50 (48 h) > 100 mg/L based on immortality of Daphnia magna (EU Method C.2)
Key value for chemical safety assessment
Additional information
One experimental study is available investigating the short-term toxicity of methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432-65-7) to aquatic invertebrates (Hertl, 2002). This study was performed according to EU Method C.2 (GLP). Daphnia magna was exposed to nominal concentrations of 4.6, 10, 21, 46 and 100 mg/l. Analysis of the dissolved organic carbon (DOC) revealed a mean recovery of 89 - 92%. Since the substance is expected to hydrolyse rapidly in contact with water (DT50: 1.9 h at 20 - 25 °C, pH 7), the result from this study mainly investigated the possible effects of the hydrolysis products (Methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate und methanol). During stock solution preparation it was ensured by intensive stirring that the parent substance hydrolyses and mainly the hydrolysis products are tested. After an exposure of 48 h no immobilisation was observed resulting in an EC50 of > 100 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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