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EC number: 457-690-5 | CAS number: 23432-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432 -65 -7) and its hydrolysis products are not harmful to aquatic organisms.
Additional information
The registered substance methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432 -65 -7) hydrolyses rapidly in contact with water (DT50 = 1.9 h at pH 7 and 20 – 25 °C, QSAR) to methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate and methanol. REACH guidance R.16 states that “for substances where hydrolytic DT50 is less than 12 h, environmental effects are likely to be attributed to the hydrolysis product rather than to the parent itself” (ECHA, 2016). TGD (EC, 2003) and REACH guidance R.16 (ECHA, 2016) also suggest that when the hydrolysis half-life is less than 12 h, the breakdown products, rather than the parent substance, should be evaluated for aquatic toxicity testing.
Data for the acute aquatic toxicity of the target substance methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432 -65 -7) is available for all three trophic levels (fish, aquatic invertebrates, algae). Due to the duration and exposure scenario of the performed short-term toxicity studies (static set-up) and the rapid hydrolyses of the parent substance, it can be assumed that the organisms were mainly exposed to the hydrolysis products. All studies were performed according to accepted standard guidelines and GLP. No acute effects (LC/EC50 values) were observed towards the tested organisms of all three trophic levels up to a concentration of 100 mg/L.
The second hydrolysis product methanol is well characterised in the public domain literature and is not hazardous at the concentrations relevant to the studies. The short-term EC50 and LC50 values for methanol are in excess of 1000 mg/l (OECD SIDS, 2004). Thus, methanol is not considered to contribute to the overall aquatic toxicity of the parent substance.
Table: Overview on aquatic effect values for methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432 -65 -7) and its hydrolysis products.
|
Parent |
Silanol hydrolysis product |
Other hydrolysis product |
CAS |
23432 -65 -7 |
|
67-56-1 |
|
methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate |
methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate |
Methanol |
Acute fish (LC 50) |
> 100 mg/L |
See parent |
> 15000 mg/L* |
Acute invertebrates (EC50) |
> 100 mg/L |
See parent |
> 10000 mg/L* |
Algae (ErC50) |
117.42 mg/L |
See parent |
ca. 22000 mg/L* |
Algae (NOErC) |
33.5 mg/L |
See parent |
No data |
* Source: OECD SIDS (2004)
No effects on activated sludge microorganisms were recorded up to a concentration of 1000 mg/L with the parent substance methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432 -65 -7). The EC50 (3 h) was found to be > 1000 mg/L. On this basis, no toxic effects are anticipated by the parent substance and the degradation process in sewage treatment plants is not considered to be inhibited.
References:
OECD SIDS, 2004: SIDS Initial Assessment Report for Methanol, SIAM 19, Berlin, Germany, 19-22 October 2004, Methanol, CAS 67-56-1Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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