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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
GESTIS for CAS: 108-69-0
Author:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance
Year:
2016
Bibliographic source:
GESTIS for CAS: 108-69-0; Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance, 2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To assess the eye irritation potential of 3,5-xylidine in rabbits according to a standardized rabbit eye test (OECD 405)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-xylidine
EC Number:
203-607-0
EC Name:
3,5-xylidine
Cas Number:
108-69-0
Molecular formula:
C8H11N
IUPAC Name:
3,5-Xylidine
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 3,5 Dimethylaniline
- Molecular formula : C8H11N
- Molecular weight : 121.182 g/mol
- Smiles notation : c1(cc(cc(c1)N)C)C
- InChl : 1S/C8H11N/c1-6-3-7(2)5-8(9)4-6/h3-5H,9H2,1-2H3
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3,5 Dimethylaniline
- Molecular formula : C8H11N
- Molecular weight : 121.182 g/mol
- Smiles notation : c1(cc(cc(c1)N)C)C
- InChl : 1S/C8H11N/c1-6-3-7(2)5-8(9)4-6/h3-5H,9H2,1-2H3
- Substance type: Organic
- Physical state: liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
In a standardized rabbit eye test (OECD 405), the undiluted 3,5-xylidine caused only slight eye irritation, which can be considered as not irritating.

Executive summary:

An eye irritation study was performed to assess the irritation potential of 3,5-xylidine in rabbits. The study was performed according toa standardized rabbit eye test (OECD 405). Undiluted 3,5-xylidine was instilled into rabbit eyes and effects were observed (duration not mentioned).

Undiluted 3,5-xylidine caused only slight eye irritation, which can be considered as not irritating.