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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

Currently viewing:

Administrative data

Endpoint:
carcinogenicity: oral
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1970
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A group of 16 rats were given doses of up to 15 mg MTS/kg by stomach tube, one a week for 2years.
Only one dose group, no controls, no histopathology reported.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl toluene-4-sulphonate
EC Number:
201-283-5
EC Name:
Methyl toluene-4-sulphonate
Cas Number:
80-48-8
Molecular formula:
C8H10O3S
IUPAC Name:
methyl 4-methylbenzene-1-sulfonate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on exposure:
16 rats were given doses of up to 15 mg MTS/kg by stomach tube, once a week for 2years
Analytical verification of doses or concentrations:
not specified
Frequency of treatment:
15 mg MTS/kg by stomach tube, once a week for 2years
Post exposure period:
not specified
Doses / concentrations
Dose / conc.:
15 mg/kg bw/day (actual dose received)
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
not specified
Dermal irritation (if dermal study):
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Neuropathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Other effects:
not specified
Description (incidence and severity):
Of 16 treated rats, only one animal is reported to have developed a malignant tumour: a fibrosarcoma under the skin of the back.
Relevance of carcinogenic effects / potential:
Unknown - Only one dose group, no controls, no histopathology reported.

Effect levels

Dose descriptor:
dose level:
Effect level:
ca. 15 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
gross pathology

Applicant's summary and conclusion

Conclusions:
A brief report of a study where a group of 16 rats were given doses of up to 15 mg MTS/kg by stomach tube, one a week for 2years, claimed that only one animal developed a malignant tumour. This was a fibrosarcoma under the skin of the back.
No information on untreated controls was given. Only one dose group, no controls, no histopathology reported. (Druckery et al 1970, cited in the BIBRA Profile).