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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Remarks:
Handbook Data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Principles of method if other than guideline:
Handbook Data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl toluene-4-sulphonate
EC Number:
201-283-5
EC Name:
Methyl toluene-4-sulphonate
Cas Number:
80-48-8
Molecular formula:
C8H10O3S
IUPAC Name:
methyl 4-methylbenzene-1-sulfonate

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Amount / concentration applied:
2 mg
Duration of treatment / exposure:
24 hours

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other:
Value:
ca.
Remarks on result:
other: Reported rabbit data - Effect:Severe

In vivo

Results
Irritation parameter:
other:
Time point:
24 h
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Severe irritation observed with 2mg application over 24 hours.

Applicant's summary and conclusion

Interpretation of results:
Category 1C (corrosive) based on GHS criteria
Conclusions:
Severe irritation observed with 2mg application over 24 hours.
Source: PrehledPrumysloveToxikologie; OrganickeLatky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986