Registration Dossier
Registration Dossier
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EC number: 202-039-0 | CAS number: 91-08-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from safety assessment reports
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toluene diisocyanate [MAK Value Documentation, 2003].
- Author:
- The MAK Collection for Occupational Health and Safety
- Year:
- 2 012
- Bibliographic source:
- The MAK Collection for Occupational Health and Safety. 292–338, 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To determine the threshold value for the irritation in humans when exposed to 2,6- Toluene diisocyanate for short duration.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6- Toluene diisocyanate
- IUPAC Name:
- 2,6- Toluene diisocyanate
- Reference substance name:
- 2-methyl-m-phenylene diisocyanate
- EC Number:
- 202-039-0
- EC Name:
- 2-methyl-m-phenylene diisocyanate
- Cas Number:
- 91-08-7
- Molecular formula:
- C9H6N2O2
- IUPAC Name:
- 1,3-diisocyanato-2-methylbenzene
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 2,6-Toluene diisocyanate
- Molecular formula: C9H6N2O2
- Molecular weight: 174.1584 g/mol
- Smiles notation: c1(cccc(c1C)N=C=O)N=C=O
- InChl: 1S/C9H6N2O2/c1-7-8(10-5-12)3-2-4-9(7)11-6-13/h2-4H,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- human
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.05 – 0.2 ml/m3 of 2,6-Toluenediisocyanate vapours
- Duration of treatment / exposure:
- 30 minutes
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 30 minutes
- Remarks on result:
- other: Severe conjunctival Irritation was observed
- Irritant / corrosive response data:
- 30 minutes of exposure to 2,6- Toluene diisocyanate caused severe conjunctival irritation to eyes.
Any other information on results incl. tables
Table 1:Effects of experimental exposure of persons to defined constant concentrations of TDI
Concentration (ml/m3) |
TDI |
Exposure duration (in minutes) |
Symptoms |
0.05 |
2,6 –TDI |
30 |
Odour and eye irritation was observed |
0.08 |
2,6 – TDI |
30 |
Slight conjunctival irritation, prickling in the nose |
0.1 |
2,6 –TDI |
30 |
Severe irritation of the eyes and nose |
0.2 |
2,6- TDI |
30 |
Severe irritation of the eyes and nose. |
where TDI - Toluene diisocyanate
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A study was conducted to determine the threshold value for the irritation in humans when exposed to 2,6- Toluene diisocyanate for short duration.
30 minutes of exposure to 2,6- Toluene diisocyanate caused severe conjunctival irritation to eyes.
Hence 2 ,6- Toluene diisocyanate was evaluated as irritating to human eyes. - Executive summary:
A study was conducted to determine the threshold value for the irritation in humans when exposed to 2,6- Toluene diisocyanate for short duration.
Human volunteers were exposed to 0.05 – 0.2 ml/m3 vapours of 2,6- Toluene diisocyanate for 30 minutes. It was seen that the irritation potential of 2,6 -Toluene diisocyanate increased gradually with the increase in concentration of the test chemical.30 minutes of exposure to 2, 6- Toluene diisocyanate caused severe conjunctival irritation to eyes.
Hence 2,6- Toluene diisocyanate was evaluated as irritating to human eyes.
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