Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No bioaccumulation potential
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Yellow LF 6881 is a orange organic powder.
Yellow LF 6881 is not toxic/harmful for short-term exposures and it is not skin/eye irritating. It is not able to cause an allergic skin reaction. No CMR activity has never been reported in literature and has been observed in specific experiments performed.
No adverse effects were observed during the experiments run, thus, mechanisms of bioactivation leading to adverse effects are not expected to occur.
Specific studies or specific literature data on toxicokinetics and metabolism are not available, thus information about the substance has been taken into account, avoiding further tests.
Because of the molecular structure and the hydrophilic of Yellow LF 6881, dermal absorption is expected to be negligible. Based on the available information, potential dermal toxicity is not suspected. Furthermore, the substance gave negative results in skin sensitisation assay, thus it is considered as not able to cause an allergic response in susceptible individuals, after exposure via the skin.
Because of the physical state and the characteristic particle size distribution, inhalation is not an appropriate route of exposure.
During the oral toxicity experiments, both acute and subacute, the treatment did not produce changes detected in health condition. Brownish-red coloured faeces was the only finding, attributable to the test item treatment, due to the elimination of test item or its metabolite by the gastrointestinal tract. The finding of coloured faeces after single dose, as well as after repeated administrations, and the almost complete absence of any other effects let to expect that the substance can be significantly excreted.
The presence of coloured stool and coloured content of stomach and intestines let to expect that the scaffold was not significantly modified by transformation; colour proves that the conjugation is not completely interrupted. However, the extension of the elimination rate of the substance as such cannot be estimated.
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