2,2-bis({[3-(4-ethylpiperazin-1-yl)propanoyl]oxy}methyl)butyl 3-(4-ethylpiperazin-1-yl)propanoate

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Test material

Test material information

Constituent 1

Reference substance name:

2,2-bis({[3-(4-ethylpiperazin-1-yl)propanoyl]oxy}methyl)butyl 3-(4-ethylpiperazin-1-yl)propanoate

EC Number:

700-404-3

Cas Number:

127929-37-7

Molecular formula:

C33H62N6O6

IUPAC Name:

2,2-bis({[3-(4-ethylpiperazin-1-yl)propanoyl]oxy}methyl)butyl 3-(4-ethylpiperazin-1-yl)propanoate

Results and discussion

Vapour pressure

Vapour pressure 1

Temp.:

<= 20 °C

Vapour pressure:

<= 0 Pa

Vapour pressure 2

Temp.:

<= 25 °C

Vapour pressure:

<= 0 Pa

Any other information on results incl. tables

The following vapour pressure were determined experimentally and considered as valid (mean and standard deviation given):

Experiment	T	P	Stand. Dev. P	RSD P
No.	K	Pa	Pa	%
1	389.3	3.97 E-03	2.35 E-04	5.9 %
2	403.5	1.28 E-02	1.28 E-03	10.0 %

For the test item B 1061, the vapour pressures at 20°C and at 25°C were calculated from the regression equation.

Applicant's summary and conclusion

Executive summary:

The vapour pressure of B 1061 was determined following EU A.4 using the effusion method (weight loss).

Two runs were performed.

In the first run with eleven experiments, vapour pressure was determined at eleven different temperatures. At lower temperatures, no weight loss was detected. At the temperatures 125 and 140 °C (nominal), weight loss was found, but it was suspected that other test items which had shown weight loss at lower temperatures might have influenced the result by contaminating the Knudsen cell. Therefore, it was decided to repeat the experiment.

In the second run with two experiments, vapour pressure was determined at the nominal temperatures 125 °C and 140 °C only. Significant and reproducible weight loss was found. As higher temperatures could not be measured due to the limits of the test system and lower temperatures would not yield significant weight loss, regression was performed over these two temperatures. The values in the table were determined experimentally. Vapour pressures at 20 °C and 25 °C were calculated from the regression equation with:

Vapour pressure at 20 °C:       7.09 E-08 Pa

Vapour pressure at 25 °C:       1.49 E-07 Pa

Both values lie below the threshold of 1 E-05 Pa.