Registration Dossier
Registration Dossier
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EC number: 617-734-8 | CAS number: 85647-38-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Overall, (Q)SAR approaches are currently not well validated for repeated dose toxicity. (Guidance on IR/CSA, Section R7.5.4.1).
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- /-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime
- EC Number:
- 617-734-8
- Cas Number:
- 85647-38-7
- Molecular formula:
- C22H29N3O3
- IUPAC Name:
- /-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 10.9 mg/kg bw/day (nominal)
- Based on:
- other: Database: Repeated Dose Toxicity (HESS)
- Basis for effect level:
- other: Oral: gavage, rat
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- According to (Q)SAR modells: QSAR Toolbox, the predicted value indicated that Hydroxy-imino-ethyl-ester causes several toxic effects (target organ toxicity). The result meets the requirement of STOT-RE Category 2.
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