Registration Dossier
Registration Dossier
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EC number: 617-734-8 | CAS number: 85647-38-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- /-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime
- EC Number:
- 617-734-8
- Cas Number:
- 85647-38-7
- Molecular formula:
- C22H29N3O3
- IUPAC Name:
- /-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime
Constituent 1
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: 2.7 %
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that hydroxy-imino-ethyl-ester is sensitiser. The result meets the requirement of Hazard Category 1B.
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