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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from J-CHECK and OECD SIDS

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Twenty-eight-day Repeat Dose Oral Toxicity Test of 2-Amino-5- methylbenzenesulfonic acid in Rats
Author:
Ministry of Health & Welfare, Japan
Year:
1996
Bibliographic source:
Ministry of Health & Welfare, Japan (1996a): Toxicity Testing Reports of Environmental Chemicals, vol.4 p99-106
Reference Type:
secondary source
Title:
Assessment Report for 4-AMINOTOLUENE-3-SULFONIC ACID CAS N°: 88-44-8
Author:
OECD SIDS
Year:
2003
Bibliographic source:
SIDS Initial Assessment Report For SIAM 16 Paris, 27-30 May 2003

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: No data
Principles of method if other than guideline:
The acute toxicity study was conducted to evaluate the toxic effects of 4-aminotoluene-3-sulphonic acid to rat
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (IUPAC name): 2-Amino-5-Methylbenzenesulfonic Acid
- Common name: p-Toluidine-m-sulfonic acid
- Molecular formula: C7H9NO3S
- Molecular weight: 187.2181 g/mol
- Smiles notation: Cc1ccc(c(c1)S(=O)(=O)O)N
- InChl: 1S/C7H9NO3S/c1-5-2-3-6(8)7(4-5)12(9,10)11/h2-4H,8H2,1H3,(H,9,10,11)
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-amino-5-methylbenzenesulfonic acid
- Molecular formula (if other than submission substance): C7H9NO3S
- Molecular weight (if other than submission substance): 187.2181 g/mole
- Substance type: Organic
- Physical state:
Purity: 99.30 wt%
- Impurities (identity and concentrations):0.70 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
- Source:Charles River Japan Inc
- Age at study initiation: 5 week old male
- Weight at study initiation: 168183 g, female 138 162 g
- Fasting period before study:
- Housing: Rats were individually housed in a wire mesh cage
- Diet (e.g. ad libitum): solid feed, ad libitum
- Water (e.g. ad libitum): water ad libitum
- Acclimation period:No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C):22 ± 3 ° C
- Humidity (%):55 ± 10%
- Air changes (per hr): ventilation frequency of 10 times or more / hour
- Photoperiod (hrs dark / hrs light): 12 hours of lighting (6 to 18 o'clock

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: sesame oil, 0.5mL/100g bw
Details on oral exposure:
No data
Doses:
12000 mg / kg bw /day
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
12 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality obsserved
Mortality:
50 % mortality obsserved at 12000 mg / kg in treated rats.
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Conclusions:
LD50 was considered to be 12000 mg/kg bw when rats were orally exposed with 4-aminotoluene-3-sulphonic acid.
Executive summary:

In acute oral toxicity study, Sprague-Dawley rats were treated with 4-aminotoluene-3-sulphonic acid in the concentration of 12000 mg /kg bw orally by gavage . 50 % mortality obsserved at 12000 mg / kg in treated rats. Therefore, LD50 was considered to be 12000 mg/kg bw when rats were orally exposed with 4-aminotoluene-3-sulphonic acid.