Registration Dossier
Registration Dossier
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EC number: 211-443-6 | CAS number: 645-45-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Inhalation Toxicity of Hydrocinnaomyl chloride in rats
- Author:
- RTECS – Registry of Toxic Effects of Chemical Substances
- Year:
- 2 017
- Bibliographic source:
- RTECS , Canadian Center for Occupational Health and Safety (CCOHS), 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The inhalation toxicity of Hydrocinnaomyl chloride was performed in rats
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- 3-phenylpropionyl chloride
- EC Number:
- 211-443-6
- EC Name:
- 3-phenylpropionyl chloride
- Cas Number:
- 645-45-4
- Molecular formula:
- C9H9ClO
- IUPAC Name:
- 3-phenylpropanoyl chloride
- Test material form:
- liquid
- Details on test material:
- 3-phenylpropanoyl chloride/645-45-4 / 211-443-6- Name of test material (as cited in study report): 3-phenylpropanoyl chloride- Molecular formula: C9H9ClO- Molecular weight: 168.622 g/mol- Substance type: organic - Physical state: Liquid- Smiles notation: c1cc(CCC(Cl)=O)ccc1- InChl: 1S/C9H9ClO/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): hydrocinnamoyl chloride- Molecular formula: C9H9ClO- Molecular weight: 168.622 g/mol- Substance type: organic - Physical state: Liquid- Smiles notation: c1cc(CCC(Cl)=O)ccc1- InChl: 1S/C9H9ClO/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- No data available
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- No data available
- Concentrations:
- 2750 mg/m3/h
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2 750 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Skin and Appendages was observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The lethal concentration causing 50% mortality (LC50) in rats after 4 h exposure to hydrocinnamoyl chloride was considered to be 2750 mg/m3/h
- Executive summary:
In the inhalation toxicity of Hydrocinnaomyl chloride was performed in rats.
The lethal concentration causing 50% mortality (LC50) in rats after 4 h exposure to hydrocinnamoyl chloride was considered to be 2750 mg/m3/h
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