1,4-divinylbenzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database.

Data source

Reference

Reference 1

Reference Type:

other: authoritative database

Title:

Acute oral toxicity by using test chemical

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

ChemIDplus

Reference 2

Reference Type:

secondary source

Title:

Toxicity Study

Author:

NTRL

Year:

1990

Bibliographic source:

NTRL

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity of test chemical in rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-Ethenylphenyl acetate

EC Number:

607-905-5

Cas Number:

2628-16-2

Molecular formula:

C10H10O2

IUPAC Name:

4-Ethenylphenyl acetate

Details on test material:

- IUPAC Name: 4-Ethenylphenyl acetate- InChI: 1S/C10H10O2/c1-3-9-4-6-10(7-5-9)12-8(2)11/h3-7H,1H2,2H3- Smiles: O=C(Oc1ccc(cc1)C=C)C- Molecular formula:C10H10O2- Molecular weight :162.187 g/mole- Substance type:Organic- Physical state:Liquid

Test animals

Species:

rat

Strain:

other: CD rat

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Age at study initiation: 4 week-old- Fasting period before study: fasted overnight

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

not specified

Doses:

700, 1000, 1429, 2014 mg/kg

No. of animals per sex per dose:

groups of 5 rats of each sex

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes, survivors were killed and necropsied.- Other examinations performed: Animals were observed for mortality and clinical signs.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 732 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

1 503 mg/kg bw

Based on:

test mat.

Effect levels 3

Sex:

female

Dose descriptor:

LD50

Effect level:

2 027 mg/kg bw

Based on:

test mat.

Mortality:

Mortality occurred within 3 days of administration.

Clinical signs:

Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity.

Body weight:

not specified

Gross pathology:

Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining.

Other findings:

not specified

Any other information on results incl. tables

Table

DOSAGE mg/kg	MORTALITY		COMMENTS
	Males	Females
700	0/5	0/5	Minimal Effects
1000	1/5	0/5	Survivors appeared normal after day 5
1429	2/5	2/5
2014	4/5	2/5	Cause of death not determined

 

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Acute oral toxicity dose (LD50) value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.

Executive summary:

Acute oral toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 700, 1000, 1429, 2014 mg/kg bw. The test chemical was dissolved incorn oil and administered via oral gavage route. Animals were observed for mortality and clinical signs for 14 days after administration of the test substance and survivors were killed and necropsied. Decedents were necropsied as soon as possible after death. Mortality occurred within 3 days of administration. Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity. Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining. Hence, LD50 value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.