Registration Dossier
Registration Dossier
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EC number: 203-266-8 | CAS number: 105-06-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity conducted in rat
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Divinylbenzene
- EC Number:
- 215-325-5
- EC Name:
- Divinylbenzene
- Cas Number:
- 1321-74-0
- Molecular formula:
- C10H10
- IUPAC Name:
- 1,2-di(ethenyl)benzene
- Details on test material:
- - IUPAC Name: Divinylbenzene- InChI: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Smiles: C=CC1=CC=CC=C1C=C- Molecular formula :C10H10- Molecular weight :131.1969 g/mole- Substance type:Organic- Physical state:Colorless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Remarks on duration:
- not specified
- Concentrations:
- 645 ppm (645000 mg/m3)
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Other examinations performed: Animals were observed for mortality and clinical signs.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 645 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 645000 mg/m3
- Clinical signs:
- other: Toxic effects were not observed.
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) value was considered to be 645 ppm (645000 mg/m3), when rats were exposed with test chemical via inhalation route by vapors for 7 hrs.
- Executive summary:
Acute Inhalation toxicity study was conducted by using test chemical in rats at the concentration of 645 ppm by inhalation route via vapors for 7 hours. Animals were observed for mortality and clinical signs. 50% mortality was observed. Toxic effects were not observed. Hence, LC50 value was considered to be 645 ppm (645000 mg/m3), when rats were exposed with test chemical via inhalation route by vapors for 7 hrs.
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