Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-059-8 | CAS number: 10026-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For the target substance niobium pentachloride acute toxicity data is available for the oral route from two publications. Zhilova, 1966 published LD50 values for the rat (1400 mg/kg bw) and mouse (829 mg/kg bw). Haley, 1962 determined the oral LD50 in male CF1 mice with 940 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication, which meets generally accepted scientifc standards
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study is an acute oral toxicity, but as the study is from 1966 no OECD guideline for acute oral toxicity was available at that time
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity
- Limit test:
- no
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no detailed information provided
- Route of administration:
- oral: unspecified
- Vehicle:
- other: vaseline oil
- Details on oral exposure:
- no data provided
- Doses:
- no data provided
- No. of animals per sex per dose:
- no data provided
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data - Statistics:
- N.A.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 829 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality occured, but no detailed information provided
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, the oral LD50 value in mice after treatment with niobium pentachloride was 829 mg/kg body weight.
- Executive summary:
In an acute oral toxicity study mice were orally exposed to niobium pentachloride in vaseline oil. Animals were observed for 14 days. Based on the results, the oral LD50 was considered to be 829 mg/kg body weight.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 829 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Two publications are available, in which rodents were treated orally with niobium pentachloride (target substance). In the publication by Zhilova, 1966 rats and mice were administered orally with the target substance and were afterwards observed for a period of 14 days. Based on mortality, the LD50 was determined to be for the rat: 1400 mg/kg bw and for the mouse: 829 mg/kg bw.
Haley, 1962 determined in an acute oral toxicity study the LD50 in male mice with 940 mg/kg bw after treatment with niobium pentachloride.
Depending on species and vehicle, LD50 values vary between 829 mg/kg and 1400 mg/kg. All values are within the LD50 range of 300 – 2000 mg/kg for acute oral toxicity category 4 according to CLP.
Justification for selection of acute toxicity – oral endpoint
Publication, which meets generally accepted scientific standards
Justification for classification or non-classification
Based on the available data, niobium pentachloride warrant classification for acute oral toxicity Category 4 (H302) in accordance to regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.