Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-909-9 | CAS number: 4548-53-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- REPORT BY THE SCIENTIFIC COMMITTEE ON COSMETOLOGY(Opinion expressed on 1. July 1986) CONCERNING CERTAIN COLOURING AGENTS
- Author:
- Directorate-General Environment, Consumer Protection and Nuclear Safety
- Year:
- 1 988
- Bibliographic source:
- Commission of the European Communities REPORTS of the Scientific Committee on Cosmetology (seventh series),1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Skin irritation test for chemical FD and C Red 4 was performed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium 3-[(2,4-dimethyl-5-sulphonatophenyl)azo]-4-hydroxynaphthalene-1-sulphonate
- EC Number:
- 224-909-9
- EC Name:
- Disodium 3-[(2,4-dimethyl-5-sulphonatophenyl)azo]-4-hydroxynaphthalene-1-sulphonate
- Cas Number:
- 4548-53-2
- Molecular formula:
- C18H16N2O7S2.2Na
- IUPAC Name:
- disodium 3-[(2,4-dimethyl-5-sulfonatophenyl)diazenyl]-4-hydroxynaphthalene-1-sulfonate
- Reference substance name:
- FD and C Red 4
- IUPAC Name:
- FD and C Red 4
- Details on test material:
- - Name of test material (as cited in study report):FD and C Red 4- Molecular formula (if other than submission substance):C18H14N207s2Na2- Molecular weight (if other than submission substance):480- Substance type:Organic- Physical state:Solid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Amount/concentration applied1.0% in formulations
- Duration of treatment / exposure:
- Daily exposure
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- no data
- Remarks on result:
- other: No skin irritation
- Irritant / corrosive response data:
- No data available
- Other effects:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Not irritating effects were known in skin irritation test of chemical FD and C red 4 exposed to the skin of rabbit.
- Executive summary:
Skin irritation test was conducted on rabbits exposed to chemical ED and C Red with 1% test chemical concentration for daily exposure.
Not irritating effects were known in skin irritation test of chemical FD and C red 4 exposed to the skin of rabbit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
