Registration Dossier
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EC number: 218-542-3 | CAS number: 2177-70-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72 h ECr10 = 5.19 mg/L (95% c.i. 3.72 - 6.37 mg/L) / 72 h ErC50 = 8.72 mg/L (95% c.i. 7.95 - 12.6 mg/L); OECD guideline 201; GLP
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 8.72 mg/L
- EC10 or NOEC for freshwater algae:
- 5.19 mg/L
Additional information
One short-term study in freshwater algae is available for PHMA, which is considered reliable without restriction (Klimisch score 1).
In a 72 hour acute toxicity study, the cultures of Desmodesmus subspicatus CHODAT SAG 86.81 were exposed to PHMA at concentrations of nominal 0 (control), 1.00, 3.16, 10.0, 31.6 and 100 mg/L, corresponding to measured (geometric mean) 0, 0.472, 1.90, 7.31, 25.5 and 79.8 mg/L under static conditions in accordance with the OECD guideline 201 (adopted 23 March 2006).
Microscopic evaluation of the cells at start and end of the incubation period revealed no morphological abnormalities.
The NOEC-values for inhibition of growth rate and yield after 72 hours were 1.90 mg/L and 0.472 mg/L, respectively.
The EC10-values for inhibition of specific growth rate (E rC10) and yield (EyC10) with 95% confidence intervals after 72 hours were 5.19 (3.72 - 6.37) and 1.35 (1.09 - 1.64) mg/L, respectively.
The EC50-values for inhibition of specific growth rate (E rC50) and yield (EyC50) with 95% confidence intervals after 72 hours were 8.72 (7.95 - 12.6) and 3.52 (3.06 - 4.07) mg/L, respectively. All effect levels are given based on geometric mean measured concentrations of PHMA.
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